Carbapenem-resistant Enterobacter cloacae complex in a tertiary Hospital in Northeast China, 2010–2019
نویسندگان
چکیده
Abstract Background Carbapenem-resistant Enterobacter cloacae complex (CREC) is a new emerging threat to global public health. The objective of the study was investigate clinical characteristics and molecular epidemiology CREC infections in medical center northeast China. Methods Twenty-nine patients were infected/colonized with during ten-year period (2010–2019) by WHONET analysis. Antibiotic susceptibilities tested VITEK 2 micro broth dilution method (for polymyxin B tigecycline). Carbapenemase encoding genes, ?-lactamase seven housekeeping genes for MLST amplified sequenced 18 cryopreserved isolates. Maximum likelihood phylogenetic tree built concentrated sequences show relatedness between Results There rapid increase detection rate period, reaching 8.11% 2018 6.48% 2019. resistance isolates imipenem meropenem 100.0 77.8%, however, they showed high sensitivity tigecycline, amikacin. 30-day crude mortality infection 17.4%, indicating that it may be low-virulence bacterium. Furthermore, revealed ST93 predominant sequence type followed ST171 ST145, NDM-1 NDM-5 as main carbapenemase-encoding genes. Moreover, E. hormaechei subsp. steigerwaltii oharae species, which different patterns. Conclusion Rising observed tertiary hospital, heterogeneity drug patterns, types. Effective prevention control measures should taken reduce spread CREC.
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2021
ISSN: ['1471-2334']
DOI: https://doi.org/10.1186/s12879-021-06250-0